Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.
The discovery that hepatitis B virus (HBV) integrates into host chromosomes raises the question of whether such viral DNA integration correlates directly with the activation of specific oncogenes or the inactivation of anti-oncogenes. To obtain insight into this problem, we randomly collected HBV integrant samples from different human hepatocellular carcinomas and identified the site of chromos...
متن کاملThe mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.
Nineteen DNA samples that carry integrated hepatitis B virus (HBV) DNA were isolated from seven independent human hepatomas by molecular cloning, and their structures were determined. The results, combined with reported data, were analyzed so that one can obtain insights into the mechanisms of integration of this virus DNA and possible rearrangements that occur subsequently. The distribution of...
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A number of risk factors appear to play a role in Hepatocellularcinoma (HCC), HBV infection being one of the most important. Chronic inflammation and cytokines are key determinants in the development of fibrosis and liver cell proliferation. HBV DNA integration and/or expression of HBV proteins may have a direct effect on cellular functions. Occult hepatitis B virus infection is characterized b...
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Chronic hepatitis B is the most common cause of hepatocellular carcinoma (HCC) in Asia. Integration of hepatitis B virus (HBV) genome is likely an early event of carcinogenesis. The integrated HBV genome may activate neighboring cellular genes directly to offer a selective growth advantage to the liver cells. Production of hepatitis B X protein can act as a transactivator on various cellular ge...
متن کاملhepatitis b virus genome asymmetry in hepatocellular carcinoma
background: the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis were reported in the literature. preference for g over c in the leading dna strand has been reported to account for the asymmetry in nucleotide (nt) composition. the aim of this study was to analyze the complete genome sequence and compositional asymmetry of hbv in different stages of hepatitis b. met...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1991
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.65.12.6761-6764.1991